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In the late 1980's, with the Soviet Union on the brink of collapse, KGB scientists sought to develop a drug that would allow their agents to drink any foe under the table, without the agents getting bombed themselves. Problem was, the KGB pill didn't stop the drunkenness. But it did prevent hangovers - not much use to spies but a boon to all the lushes clogging Moscow's bars. Now available stateside as RU-21 these pills neutralize acetaldehyde, a toxic byproduct that's been linked to cirrhosis of the liver, cancer, brain damage - and hangovers. Just pop a few and kiss mornings of splitting headaches and turbulent bowels goodbye.
David Swanson
ROLLING STONE OCTOBER 2, 2003
THE 2003 HOT LIST The secrets of the pill were declassified in 1999, and it was developed into a market commodity by scientists at the Russian Academy of Sciences as part of an extended study of alcohol's effects on the body. Its makers and Californian marketers say it is selling to the tune of $10,000 (£6,000) a week.
The Guardian NewsPaper UK
RU 21 hangover pills
 RU-21 receives coverage from Rolling Stone, GQ, Maxim, and InStyle.

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James Bond may have had X-ray sunglasses and rocket-firing cigarettes, but for years his counterparts from behind the Iron Curtain were popping pills that made them impervious to ... hangovers.
Moscow Times
A drug created by the former KGB to keep its agents sober is being sold on the Internet at tryRU21.com to Hollywood stars as a hangover defense, a report said Tuesday.
Washington Times
Worldwide Television Reports Television news reports about RU-21, averaging over 4 minutes in length, were shown on hundreds of channels worldwide, including the following networks:
CNN
ABC (World News Tonight)
CBS
FOX
NBC
PBS 13
ESPN
TECHTV
BBC World News
CTV (Canada)
Phoenix (China)
SBC (S. Korea)
Dutch National TV
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